a Record control number 000262535300010

a ISSN 0315-162X

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number WE 544

b Item number .S97 2009

a Personal name İçen, Murat.

h Medium Electronic Document

a Title Time Trends in Epidemiology and Characteristics of Psoriatic Arthritis Over 3 Decades: A Population-based Stud.

c Statement of responsibility, etc Floranne C. Wilson, Murat Icen, Cynthia S. Crowson, Marian T. McEvoy, Sherine E.Gabriel, Hilal Maradit Kremers.

c Date of publication, distribution, etc 2009.

b Name of publisher, distributor, etc Rheumatol Publ Co.,

a Place of publication, distribution, etc Toronto :

a Summary, etc Objective. Features of systemic lupus erythematosus (SLE) are commonly observed in patients with rheumatoid arthritis (RA). However, their frequency and clinical significance are uncertain. We examined the frequency of SLE features in RA and their effect on overall mortality. Methods. We assembled a population-based incidence cohort of subjects aged >= 18 years first diagnosed with RA [1987 American College of Rheumatology (ACR) criterial between 1955 and 1995. Information regarding disease characteristics. therapy, comorbidities, and SLE features (1982 ACR criteria) were collected from the complete inpatient and outpatient medical records. Cox regression models were used to estimate the mortality risk associated with lupus features. Results. The study population comprised 603 subjects with incident RA (mean age 58 yrs, 73% women) with a mean followup time of 15 years. By 25 years after RA incidence, >= 4 SLE features were observed in 15.5% of the subjects with RA. After adjustment for age and sex, occurrence of >= 4 SLE features was associated with increased overall mortality [hazard ratio (HR) 5.54, 95% confidence interval (CI) 3.59-8.53]. With further adjustment for RA characteristics, therapy, and comorbidities, the association weakened but remained statistically significant (HR 2.56, 95% Cl 1.60-4.08). After adjustment for age, sex, RA characteristics, therapy, and comorbidities, thrombocytopenia (2.0, 95% CI 1.21, 3.1) and proteinuria (1.8, 95% CI 1.3, 2.6) were significantly associated with mortality. Conclusion. SLE features were common in RA, given sufficient observation time. Subjects with RA who developed >= 4 SLE features had an increased risk of death. Proteinuria and thrombocytopenia were individually associated with an increased mortality risk. (First Release Nov 1 2008; J Rheumatol 2009;36:50-57; doi: 10.3899/jrheum.080091)

a Topical term or geographic name as entry element Rheumatology.

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

a Topical term or geographic name as entry element Rheumatoid arthritis.

a Topical term or geographic name as entry element Systemic lupus erythematosus

a Main entry heading Journal Of Rheumatology

g Relationship information JAN 2009, Vol 36 Issue 1, p50-57

x International Standard Serial Number 0315162X

u Uniform Resource Identifier http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.3899/jrheum.080091